Research & Technology

Hikal has robust capabilities in research and technology


Our Research & Technology division partners with innovator companies in pharmaceuticals, specialty chemicals and animal health areas to develop innovative, cost effective and safe processes for NCEs, generic molecules as well as provide life cycle management for existing molecules for global clients.

Client first

Hikal has an impeccable track record of delivering active pharmaceutical ingredients (APIs), active ingredients (AIs) and intermediates to global clients with outmost confidentiality. Our facilities are built to meet the specific needs of clients and stringent requirements of the United States, European, and Japanese markets.

Green chemistry

Our comprehensive environment, health and safety (EHS) policy ensures that the interests of all constituents are safeguarded. Processes are developed at our R&T centre with significant focus on process understanding with a view to increasing yield and throughput as also on optimization of effluent treatability processes. We use statistical analysis tools like DOE for optimizing process development. Strong mechanistic understanding and use of process simulation tools render scaleup facile and efficient. We try to imbibe the 12 principles of Green Chemistry during the process development. We are the only company from India that is part of the ACS GCPRI (American Chemical Society Green Chemistry Pharma Roundtable Institute), the activities of which reflect its member's shared belief that the pursuit of green chemistry and engineering is imperative for business and environmental sustainability. Additionally, we also focus on waste treatability as part of our development projects and ensure that it is a part of the lab report before scaleup.


Our research & technology capabilities blend expertise in chemistry with advanced facilities.

Infrastructure Labs
Synthetic laboratory 11
Analytical lab 4
Process intensification lab 1
Kilo lab 2 (including 1 cGMP kilo lab)
High pressure lab 1
Solid state lab 1
Particle size engineering lab 1
Biocatalysis lab 1
Continuous Manufacturing Lab 1 (under installation)

Biocatalysis capabilities

  • Expertise in handling enzymes from lab scale to commercial manufacturing
  • Commercialized two APIs using enzymatic processes in two stages and a few are in the pipeline
  • Collaborating with world-renowned companies for Enzyme Engineering

Analytical instruments

  • HPLC
  • GC
  • GCMS
  • UPLC
  • LCMS
  • NMR 400 MHz
  • XRPD
  • Malvern particle size analyzer
  • Microbial analyzer (outsourced)
  • High Resolution Mass Spectrometry (HRMS) (outsourced)
  • ICP-MS (outsourced)
  • IC (outsourced)
  • RC1e (outsourced)
  • Hot stage microscope
  • Optimax reactor system with Huber chiller, Turbidity probes, FBRM probe, HF-Cal Kit, pH probe

Technical capabilities

  • Ammoxidation (Gas/ Solid phase)
  • Asymmetric Hydrogenation
  • Asymmetric Synthesis
  • Azide Chemistry
  • Balz-Schiemann Reaction
  • Bromination
  • Carbon Disulphide Reactions
  • Chlorination
  • Cyanide Chemistry
  • Enzyme Reactions
  • Grignard and Organolithium Reactions
  • Halex Reaction
  • High Temperature and Pressure Ammonolysis
  • Hofmann Rearrangement
  • Hydrogenation
  • Isonitrile Synthesis
  • Macrolide Chemistry
  • Organo-phosphorus Chemistry
  • Oxidation Reactions
  • Reductive Amination
  • Sandmeyer Reaction

Scale-up facilities

Hikal’s Kilo lab(s) in Pune allows scale-up of processes at our R&T labs and transfer of technology from global clients using advanced facilities:

  • 20 liter glass reactors
  • 50 liter glass reactors (2)
  • Heating/cooling system: –90°C to +200°C
  • 20 liter high vacuum distillation unit
  • Pressure Nutsche filter, centrifuge
  • Vacuum tray dryer
  • Miller and sifter
  • Double-cone drier

Hikal is in the process of installing a pilot scale PP and FBR in R&T that should be operational sometime in 2020. Hikal is in the process of installing a pilot scale FBR in R&T for development & optimization of the process.

Process Safety

Hikal gives utmost importance to Safety while development of processes at R&T. We use below tools (in-house or outsourced) to assess safety of the developed processes:

  • Desk Screening
  • Thermal Screening (DSC/ TGA)
  • Powder Safety Testing
  • Optimax having HF Cal software as a surrogate to RC1e
  • Available Software (Dynochem)

Continuous Laboratory

  • Plug Flow Reactors
  • Vapourtec for Rapid Screening
  • Zaiput Membrane for Separation
  • CSTR
  • Lab scale Fixed Bed Reactor that is based on Hikal’s commercial fixed bed vapor reactor has an annual capacity of 1,000 MT: Material of construction: Stainless steel SS 316.Undertakes chemical reactions with efficient control as required over a vapor phase. Used primarily for ammoxidation reaction (catalyst CoMo/Vanadium) – production of nitrile using ammonia and oxygen. Operation temperature 380 – 420°C

Two continuous processes have been commercialized Hikal gives importance to update the knowledge using the different search engines/ tools during product development as follows :

  • Newport
  • Scifinder
  • Reaxys (accessible to all the scientists)
  • Design expert
  • Questel
  • Orbit
  • INPASS, etc