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R & D > Custom Synthesis
Hikal undertakes custom synthesis of key intermediates and active substances for innovator companies worldwide. We have the expertise in synthesizing diverse classes of molecules and offer gram to ton quantities in a cost-effective manner.

Pilot Plant
Our Class 100,000 cGMP Pilot Plant offers scale up capabilities and provides validation quantities required for DMF filings. This state-of-the-art plant includes stainless steel and glass lined reactors from 100L to 1,000L and undertakes multi-step synthesis. The plant is PLC controlled and the powder processing facilities include stainless steel and halar lined centrifuges, fluidized bed dryer, nauta dryer, multimill and airjet mill.

The reactions that we undertake include:

Ammoxidation Schiemann Reaction
Nitration Friedel-Crafts Reaction
Liquid phase Oppenauer oxidation Amino acid transformation
Swern oxidation Ortho metalation process
High temperature/high pressure oxidation Aldol Condensation
Suzuki reaction Hazardous materials handling:
Birch reduction      -   Chlorine
Catalytic hydrogenation      -   Bromine
Darzens glycidic ester condensation      -   Chlorosulfonic acid
Sandmeyer reaction      -   Cyanogen chloride
Chiral synthesis      -   Carbon disulfide
Hetero Diels Alder Reaction Low temperature reaction; -100°c
1,3 polar addition High temperature reaction; +280°c
Mannich reaction High pressure reaction; 30kg/cm2(g)

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